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1

Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1

Hugues Ouellet, Petrea M. Kells, Paul R. Ortiz de Montellano, Larissa M. Podust

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 711 KB

english, 2011

2

Structure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric Intermediate

Petrea M. Kells, Hugues Ouellet, Javier Santos-Aberturas, Jesus F. Aparicio, Larissa M. Podust

Journal:

Chemistry & Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2010

3

Substrate recognition sites in 14α-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51

Larissa M Podust, Jure Stojan, Thomas L Poulos, Michael R Waterman

Journal:

Journal of Inorganic Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 3.42 MB

english, 2001

4

Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one

Hugues Ouellet, Shenheng Guan, Jonathan B. Johnston, Eric D. Chow, Petrea M. Kells, Alma L. Burlingame, Jeffery S. Cox, Larissa M. Podust, Paul R. Ortiz De Montellano

Journal:

Molecular Microbiology

Année:

2010

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2010

5

Diversity of P450 enzymes in the biosynthesis of natural products

Podust, Larissa M., Sherman, David H.

Journal:

Natural Product Reports

Année:

2012

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2012

6

Estriol Bound and Ligand-free Structures of Sterol 14α-Demethylase

Larissa M. Podust, Liudmila V. Yermalitskaya, Galina I. Lepesheva, Vladimir N. Podust, Enrique A. Dalmasso, Michael R. Waterman

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 542 KB

english, 2004

7

A Second FMN Binding Site in Yeast NADPH-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases

David C. Lamb, Youngchang Kim, Liudmila V. Yermalitskaya, Valery N. Yermalitsky, Galina I. Lepesheva, Steven L. Kelly, Michael R. Waterman, Larissa M. Podust

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 902 KB

english, 2006

8

Structural control of cytochrome P450-catalyzed ω-hydroxylation

Jonathan B. Johnston, Hugues Ouellet, Larissa M. Podust, Paul R. Ortiz de Montellano

Journal:

Archives of Biochemistry and Biophysics

Année:

2011

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2011

9

Comparison of the 1.85 Å structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways

Larissa M. Podust, Horacio Bach, Youngchang Kim, David C. Lamb, Miharu Arase, David H. Sherman, Steven L. Kelly, Michael R. Waterman

Journal:

Protein Science

Année:

2004

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2004

10

A highly conserved mycobacterial cholesterol catabolic pathway

García-Fernández, Esther, Frank, Daniel J., Galán, Beatriz, Kells, Petrea M., Podust, Larissa M., García, José L., Ortiz de Montellano, Paul R.

Journal:

Environmental Microbiology

Année:

2013

Langue:

english

Fichier:

PDF, 1.96 MB

english, 2013

11

Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents

Choi, Jun Yong, Calvet, Claudia M., Gunatilleke, Shamila S., Ruiz, Claudia, Cameron, Michael D., McKerrow, James H., Podust, Larissa M., Roush, William R.

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 4.14 MB

english, 2013

12

R -Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi

Choi, Jun Yong, Calvet, Claudia M., Vieira, Debora F., Gunatilleke, Shamila S., Cameron, Michael D., McKerrow, James H., Podust, Larissa M., Roush, William R.

Journal:

ACS Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2014

13

Expanding the Binding Envelope of CYP51 Inhibitors Targeting Trypanosoma cruzi with 4-Aminopyridyl-Based Sulfonamide Derivatives

Vieira, Debora F., Choi, Jun Yong, Roush, William R., Podust, Larissa M.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.78 MB

english, 2014

14

Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation

Negretti, Solymar, Narayan, Alison R. H., Chiou, Karoline C., Kells, Petrea M., Stachowski, Jessica L., Hansen, Douglas A., Podust, Larissa M., Montgomery, John, Sherman, David H.

Journal:

Journal of the American Chemical Society

Année:

2014

Langue:

english

Fichier:

PDF, 930 KB

english, 2014

15

Uncovering the broader roles of redox partner proteins for cytochrome P450 enzymes

Li, Shengying, Zhang, Wei, Liu, Yi, Anzai, Yojiro, Kato, Fumio, Podust, Larissa, Sherman, David

Journal:

New Biotechnology

Année:

2014

Langue:

english

Fichier:

PDF, 71 KB

english, 2014

16

FMN Binding Site of Yeast NADPH-Cytochrome P450 Reductase Exposed at the Surface Is Highly Specific

Ivanov, Alexis S., Gnedenko, Oksana V., Molnar, Andrey A., Archakov, Alexander I., Podust, Larissa M.

Journal:

ACS Chemical Biology

Année:

2010

Langue:

english

Fichier:

PDF, 2.54 MB

english, 2010

17

New Reactions and Products Resulting from Alternative Interactions between the P450 Enzyme and Redox Partners

Zhang, Wei, Liu, Yi, Yan, Jinyong, Cao, Shaona, Bai, Fali, Yang, Ying, Huang, Shaohua, Yao, Lishan, Anzai, Yojiro, Kato, Fumio, Podust, Larissa M., Sherman, David H., Li, Shengying

Journal:

Journal of the American Chemical Society

Année:

2014

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2014

18

DNA polymerase .delta. holoenzyme: action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases

Podust, Vladimir N., Podust, Larissa M., Mueller, Friedemann, Huebscher, Ulrich

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 3.93 MB

english, 1995

19

2.3 Å X-ray Structure of the Heme-Bound GAF Domain of Sensory Histidine Kinase DosT of Mycobacterium tuberculosis †‡

Podust, Larissa M., Ioanoviciu, Alexandra, Ortiz de Montellano, Paul R.

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 6.15 MB

english, 2008

20

Mechanism of Inhibition of Proliferating Cell Nuclear Antigen-Dependent DNA Synthesis by the Cyclin-Dependent Kinase Inhibitor p21

Podust, Vladimir N., Podust, Larissa M., Goubin, Francoise, Ducommun, Bernard, Huebscher, Ulrich

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 3.58 MB

english, 1995

21

Engineering and Analysis of a Self-Sufficient Biosynthetic Cytochrome P450 PikC Fused to the RhFRED Reductase Domain

Li, Shengying, Podust, Larissa M., Sherman, David H.

Journal:

Journal of the American Chemical Society

Année:

2007

Langue:

english

Fichier:

PDF, 60 KB

english, 2007

22

Ligand-Assisted Inhibition in Cytochrome P450 158A2 from Streptomyces coelicolor A3(2) †,‡

Zhao, Bin, Waterman, Michael R., Isin, Emre M., Sundaramoorthy, Munirathinam, Podust, Larissa M.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 775 KB

english, 2006

23

Drug Strategies Targeting CYP51 in Neglected Tropical Diseases

Choi, Jun Yong, Podust, Larissa M., Roush, William R.

Journal:

Chemical Reviews

Année:

2014

Langue:

english

Fichier:

PDF, 8.84 MB

english, 2014

24

Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes

Carlson, Jacob C., Li, Shengying, Gunatilleke, Shamila S., Anzai, Yojiro, Burr, Douglas A., Podust, Larissa M., Sherman, David H.

Journal:

Nature Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2011

25

Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations

Narayan, Alison R. H., Jiménez-Osés, Gonzalo, Liu, Peng, Negretti, Solymar, Zhao, Wanxiang, Gilbert, Michael M., Ramabhadran, Raghunath O., Yang, Yun-Fang, Furan, Lawrence R., Li, Zhe, Podust, Larissa

Journal:

Nature Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 7.04 MB

english, 2015

26

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

Chen, Chiung-Kuang, Leung, Siegfried S. F., Guilbert, Christophe, Jacobson, Matthew P., McKerrow, James H., Podust, Larissa M., Geary, Timothy G.

Journal:

PLoS Neglected Tropical Diseases

Année:

2010

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2010

27

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action

Parsonage, Derek, Sheng, Fang, Hirata, Ken, Debnath, Anjan, McKerrow, James H., Reed, Sharon L., Abagyan, Ruben, Poole, Leslie B., Podust, Larissa M.

Journal:

Journal of Structural Biology

Année:

2016

Langue:

english

Fichier:

PDF, 2.71 MB

english, 2016

28

Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway

DeMars, Matthew D., Sheng, Fang, Park, Sung Ryeol, Lowell, Andrew N., Podust, Larissa M., Sherman, David H.

Journal:

ACS Chemical Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2016

29

Sterol 14α-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family

LAMB, David C., FOWLER, Kay, KIESER, Tobias, MANNING, Nigel, PODUST, Larissa M., WATERMAN, Michael R., KELLY, Diane E., KELLY, Steven L.

Journal:

Biochemical Journal

Année:

2002

Langue:

english

Fichier:

PDF, 333 KB

english, 2002

30

Solution conformations and dynamics of substrate-bound cytochrome P450 MycG

Tietz, Drew R., Podust, Larissa M., Sherman, David H., Pochapsky, Thomas C.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 2.73 MB

english, 2017

31

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

Chen, Chiung-Kuang, Doyle, Patricia S., Yermalitskaya, Liudmila V., Mackey, Zachary B., Ang, Kenny K. H., McKerrow, James H., Podust, Larissa M., Matlashewski, Greg

Journal:

PLoS Neglected Tropical Diseases

Année:

2009

Langue:

english

Fichier:

PDF, 585 KB

english, 2009

32

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development

Ziniel, Peter D., Karumudi, Bhargava, Barnard, Andrew H., Fisher, Ethan M. S., Thatcher, Gregory R. J., Podust, Larissa M., Williams, David L., Dalton, John Pius

Journal:

PLoS Neglected Tropical Diseases

Année:

2015

Langue:

english

Fichier:

PDF, 1.86 MB

english, 2015

33

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

Zhou, Wenxu, Debnath, Anjan, Jennings, Gareth, Hahn, Hye Jee, Vanderloop, Boden H., Chaudhuri, Minu, Nes, W. David, Podust, Larissa M., Petri, William A.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 7.71 MB

english, 2018

34

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

DeMars, Matthew D., Samora, Nathan L., Yang, Song, Garcia-Borràs, Marc, Sanders, Jacob N., Houk, K. N., Podust, Larissa M., Sherman, David H.

Journal:

Journal of Biological Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 1.76 MB

english, 2019

35

Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase

Davydov, Roman M., Jennings, Gareth, Hoffman, Brian M., Podust, Larissa M.

Journal:

Archives of Biochemistry and Biophysics

Année:

2019

Langue:

english

Fichier:

PDF, 862 KB

english, 2019

36

Identification of four amoebicidal non-toxic compounds by a molecular docking screen of Naegleria fowleri sterol Δ8−Δ7-isomerase and phenotypic assays

Shi, Da, Chahal, Kirti Kandhwal, Oto, Patricia, Nothias, Louis-Félix, Debnath, Anjan, McKerrow, James H., Podust, Larissa M., Abagyan, Ruben

Journal:

ACS Infectious Diseases

Année:

2019

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2019

37

Identification of four amoebicidal non-toxic compounds by a molecular docking screen of Naegleria fowleri sterol Δ8−Δ7-isomerase and phenotypic assays

Shi, Da, Chahal, Kirti Kandhwal, Oto, Patricia, Nothias, Louis-Félix, Debnath, Anjan, McKerrow, James H., Podust, Larissa M., Abagyan, Ruben

Journal:

ACS Infectious Diseases

Année:

2019

Fichier:

PDF, 1.37 MB

2019

38

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

Corpuz, Joshua C., Podust, Larissa M., Davis, Tony D., Jaremko, Matt J., Burkart, Michael D.

Journal:

RSC Chemical Biology

Année:

2020

Fichier:

PDF, 3.67 MB

2020

39

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

Shing, Brian, Singh, Seema, Podust, Larissa M., McKerrow, James H., Debnath, Anjan

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2020

Fichier:

PDF, 2.87 MB

2020

40

HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri

Hahn, Hye Jee, Abagyan, Ruben, Podust, Larissa M., Roy, Shantanu, Ali, Ibne, Debnath, Anjan

Journal:

ACS Chemical Neuroscience

Année:

2020

Fichier:

PDF, 716 KB

2020

41

Domain-swap dimerization of Acanthamoeba castellanii CYP51 and a unique mechanism of inactivation by isavuconazole

Sharma, Vandna, Shing, Brian, Hernandez-Alvarez, Lilian, Debnath, Anjan, Podust, Larissa M.

Journal:

Molecular Pharmacology

Année:

2020

Fichier:

PDF, 15.92 MB

2020

42

Molecular Basis of Iterative CâH Oxidation by TamI, a Multifunctional P450 Monooxygenase from the Tirandamycin Biosynthetic Pathway

Newmister, Sean A., Srivastava, Kinshuk Raj, Espinoza, Rosa V., Caddell Haatveit, Kersti, Khatri, Yogan, Martini, Rachel M., Garcia-BorrÃ s, Marc, Podust, Larissa M., Houk, K. N., Sherman, David. H.

Journal:

Année:

2020

Fichier:

PDF, 2.61 MB

2020